Chronic renal disease in the general population. Importance of the absolute estimated glomerular giltration rate

Abstract

Introduction: We assessed the prevalence of the Chronic Renal Disease (CRD) in the general population and the association with known risk factors. We determined the use of the absolute estimated glomerular filtration rate (absolute eGFR). Methods: We used the MDRD formula with 4 variables corrected for body surface area of the examined individual. The population with absolute eGFR < 60 mL/min was defined as “Likely CRD regardless proteinuria” and the latter plus the population with absolute eGFR = 60 mL/min presenting proteinuria = 30 mg/L was defined as “Likely CRD considering proteinuria”. Univariate and multivariate logistic regression to determine the association between absolute eGFR <60 mL/min with comorbid factors. Results: 811 individuals of an average age of 52.5 ± 17.0 years were examined. The rate of likely CRD without consideration of pathological proteinuria is 11.7% (95% CI:9.5 -14.3) while the rate considering this factor is 15.8% (95% CI:13.2 -18.8). The 3a group (absolute eGFR 45-59 mL/min) was the most frequent one: 9.9 % (95% CI:7.8 -12.3). The significant predictive factors for absolute eGFR <60 mL/min in the
multivariate model are: older age, past or current urinary lithiasis, female gender and history of neoplasia. The relative eGFR (mL/min/1.73m2) showed a likely CRD rate without consideration of proteinuria of 12.8% (95% CI: 10.48 -15.54), 1.1% higher than observed for absolute eGFR. Conclusions: The prevalence of potential CRD is high in Santa Fe. The older age, either past or current urinary lithiasis, female gender and history of neoplasia are associated with absolute eGFR <60 mL/min. Absolute eGFR helps to reduce the rate of likely CRD in 1.1%.