Living donor kidney transplantation: Why potential donors and recipients do not achieve it. Malatya Algorithm

  • Arife Simsek Inonu University, School of Medicine, Department of General Surgery, Malatya, Turquía
  • Sait Murat Doğan Inonu University, School of Medicine, Department of General Surgery, Malatya, Turkey
  • Huseyin Gurbu Inonu University, School of Medicine, Department of Transplant Coordinator of General Surgery, Malatya, Turkey
  • Ozkan Ulutas Inonu University, School of Medicine, Division of Nephrology, Malatya, Turkey
  • Sibel Toplu Inonu University, School of Medicine, Department of İnfectious Diseases, Malatya, Turkey
  • Aslı Turgut Inonu University, School of Medicine, Division of Nephrology, Malatya, Turkey
  • Ismail Okan Yıldırım Inonu University, School of Medicine, Department of Radiology, Malatya, Turkey
  • Yasar Bayindir Inonu University, School of Medicine, Department of İnfectious Diseases, Malatya, Turkey
  • Hulya Taskapan Inonu University, School of Medicine, Division of Nephrology, Malatya, Turkey
  • Idris Sahin Inonu University, School of Medicine, Division of Nephrology, Malatya, Turkey
  • Bulent Unal Inonu University, School of Medicine, Department of General Surgery, Malatya, Turkey
  • Turgut Piskin Inonu University, School of Medicine, Department of General Surgery, Malatya, Turkey
Keywords: kidney transplant, living kidney donor, transplant programs, organ transplant, Malatya Algorithm

Abstract

Introduction: In some countries, organ donation is not widespread enough due to medical, cultural, ethical and socioeconomic factors. Living-donor kidney transplant constitutes the main source of kidney donation. Aim: To evaluate the causes of cancellation of living-donor kidney transplant and improve the effectiveness of transplant programs. Methods: Medical records of possible donors and recipients who were evaluated for living-donor kidney transplant at a tertiary medical center between November 2010 and September 2019 were reviewed retrospectively. Results: Evaluations were performed on 364 potential donors and 338 living-donor kidney transplant recipients; 207 of the latter (61.24%) underwent living-donor kidney transplant. Immune disorders represented the majority of cancellations (38.84%). Fifty-six donors (15.38%) were rejected mainly due to renal disorders (39%). Conclusion: Timely referral of patients to transplant centers must be guaranteed in order to overcome immune problems. Transplant centers should invest in programs adequate both for their resources and for their patients: paired kidney exchange, desensitization protocols, future research, etc.

References

Schena FP. Epidemiology of end‐stage renal disease: international comparisons of renal replacement therapy. Kidney Int. 2000;57(Suppl. 74):S39-S45. doi: 10.1046/j.1523-1755.2000.07407.x.

Global Observatory on Donation and Transplantation. International report on organ donation and transplantation activities, executive summary 2017 [Internet]. Disponible en: http://www.transplant-observatory.org/ (consulta: 25/03/2020).

OPTN/UNOS (Organ Procurement and Transplantation Network)/United Network for Organ Sharing) National Data Reports, Transplants by Donor Type, latest data 2017 [Internet]. Disponible en: https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/ (consulta: 25/03/2020).

Ciszek M, Pączek L, Łuków P, Rowiński W. Effective optimization of living donor kidney transplantation activity ensuring adequate donor safety. Ann Transplant. 2012;17(3):103-10. doi: 10.12659/aot.883464.

Friedman AL, Peters TG, Jones KW, Boulware LE, Ratner LE. Fatal and nonfatal hemorrhagic complications of living kidney donation. Ann Surg. 2006;243(1):126-30. doi: 10.1097/01.sla.0000193841.43474.ec.

Muzaale AD, Massie AB, Wang MC, Montgomery RA, McBride MA, L Wainrigh JL, et al. Risk of end-stage renal disease following live kidney donation. JAMA. 2014;311(6):579-86. doi: 10.1001/jama.2013.285141.

Mjøen G, Hallan S, Hartmann A, Foss A, Midtvedt K, Øyen O, et al. Long-term risks for kidney donors. Kidney Int. 2014;86(1):162-7. doi: 10.1038/ki.2013.460.

Ethics Committee of the Transplantation Society. The consensus statement of the Amsterdam Forum on the Care of the Live Kidney Donor. Transplantation. 2004;78(4):491-2. doi: 10.1097/01.tp.0000136654.85459.1e.

Turkish Transplantation Foundation. [Statistics, 2002-2018 Turkey tables and graphs related to organ donation and transplantation] [Internet]. Disponible en: http://www.tonv.org.tr/tr/organ-bagisi/istatistikler (consulta: 25/03/2020).

Council of Europe Reference Documents; European Directorate for the Quality of Medicines. Kidney Exchange Programmes in Europe Position Paper of the Council of Europe European Committee on Organ Transplantation (CD-P-TO). Newsletter Transplant. 2018;23(1):76-80.

Published
2020-12-15
How to Cite
1.
Simsek A, Doğan SM, Gurbu H, Ulutas O, Toplu S, Turgut A, Yıldırım IO, Bayindir Y, Taskapan H, Sahin I, Unal B, Piskin T. Living donor kidney transplantation: Why potential donors and recipients do not achieve it. Malatya Algorithm. Rev Nefrol Dial Traspl. [Internet]. 2020Dec.15 [cited 2024Dec.27];40(4):304-10. Available from: http://vps-1689312-x.dattaweb.com/index.php/rndt/article/view/572
Issue
Vol. 40 No. 4 (2020): Oct. - Dic.
Section
Original Article

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