New therapeutic strategies to treat hyperphosphatemia in CRF: focus on intestinal absorption

Keywords: hyperphosphatemia; intestinal absorption of phosphorus; nicotinamide; tenapanor; Sodium/phosphate cotransporter

Abstract

Introduction: Detection of anxiety and depression in the recipient-donor pair (BinRD) during the kidney transplant protocol (KT) is important to establish psychoeducational interventions that help achieve success during and after KT. Objective: To determine the presence of anxiety and depression symptoms in the BinRD during the RT protocol and to identify characteristics and associated factors. Methods: Cross-sectional study, including 174 binomials being evaluated for TR. The Beck Depression Scale (BDI-II) and the Hospital Anxiety and Depression Scale (HADS) were applied at the beginning of the RT protocol. Results: Anxiety and depression symptoms were more frequent in recipient candidates than in donors ([anxiety 39% vs 21%] [depression 46% vs 15%]) (p<0.0001). The recipients presented a higher risk of depression (OR=4.770, 95% CI 2.854-7.974, p<0.0001) and anxiety (OR=2.383, 95% CI 1.478-3.841, p<0.001). Undertaking hemodialysis in private units (OR 0.264, 95%CI 0.106-0.662, p=0.004) or being on automated peritoneal dialysis (OR 0.386, 95%CI 0.173-0.862, p=0.020 was associated with less anxiety in recipients. Conclusions: a high frequency of anxiety and depression symptoms in the BinRD, so it is important to offer effective psychological interventions focused especially on the recipient during the donation evaluation process

Published
2023-03-15
How to Cite
1.
Negri AL. New therapeutic strategies to treat hyperphosphatemia in CRF: focus on intestinal absorption. Rev Nefrol Dial Traspl. [Internet]. 2023Mar.15 [cited 2024Dec.27];43(01):57-2. Available from: http://vps-1689312-x.dattaweb.com/index.php/rndt/article/view/892
Section
Review Article