Comparison of different kidn ey diseases in patients with COVID-19: Clinical and radiological CT scores assessment

Abstract

Background: We aimed to investigate the clinical course and radiological involvements in different kidney diseases during the COVID-19 infection. Materials and Methods: The present study was conducted on 107 patients with COVID-19 having different kidney disease courses. Thirty patients with chronic kidney disease (CKD), 38 patients with maintenance hemodialysis (MHD), and 39 patients with renal transplantation (RT) were compared. Data on demographic characteristics, blood markers, in-hospital mortality and morbidities, and thorax CT scores were obtained. Results: RT patients were younger than the CKD groups (47.0 ± 11.4 vs. 71.8 ± 11.5 years, respectively; < 0.001) and MHD patients (67.7 ± 10.2 years, p < 0.001). C-reactive protein, procalcitonin, D-dimer, and ferritin values were significantly lower in RT patients (p < 0.05). The acute kidney injury rate was lower in RT patients than in CKD (p = 0.007), and the rate of sepsis development was low compared to MHD and CKD groups (p = 0.004). The requirement for mechanical ventilation (p = 0.013) and the mortality rate were significantly lower in RT patients than in MHD patients (p = 0.008). Concerning total thorax CT score, there was no difference in MHD patients compared to other groups, whereas it was found to be lower in RT patients than in CKD (p = 0.002). Conclusion: The prognosis of COVID-19 infection varies in different kidney diseases regarding morbidity, mortality, and radiologic involvement.