Effects of AGLP1 in patients with diabetic kidney disease regarding renal prognosis

Abstract

Nowadays, there are multiple families of drugs for treating diabetes mellitus type 2, each of which has different therapeutic targets, highlighting the GLP1 receptor agonists (aGLP1). The main objective of this project was to study the effect of GLP1 receptor agonists in patients with diabetic kidney disease concerning renal prognosis. A historical cohort study, in which a group of patients with diabetic kidney disease whose treatment includes aGLP1 was compared to another group of patients with the same underlying disease whose treatment of diabetes mellitus type 2 does not include aGLP1. In the results, we observed that the presence of aGLP1 in the treatment supposes a RR of 0.057 (CI 0.008-0.394) compared with the group without aGLP1 (RR 17.55, CI 2.537-121.383) concerning the production of a deterioration of the glomerular filtration rate (GFR) >20%; as well as a RR of 0.285 (CI 0.126-0.645) comparing the treatment group without aGLP1 (RR 3.51, CI 1.551-7.942) with the increase in albuminuria >10%. In short, GLP1 agonists present benefits not only in glycemic control and cardiovascular risk but also with renal prognosis independently.