Intestinal Kaposi’s Sarcoma in renal transplant patient

  • María Isabel Sáez Calero Servicio de Nefrología, Hospital Universitario de Burgos, Burgos
  • Antonio José Marín Franco Servicio de Nefrología, Hospital Universitario de Burgos, Burgos
  • José Javier Santos Barajas Servicio de Nefrología, Hospital Universitario de Burgos, Burgos
  • Gabriel Yépez León Servicio de Nefrología, Hospital Universitario de Burgos, Burgos
  • Guadalupe Tabernero Fernández Servicio de Nefrología, Hospital Clínico Universitario de Salamanca, Salamanca
  • Johanna Beatriz Palacios Ball Servicio de Anatomía Patológica. Hospital Universitario de Burgos, Burgos
  • Pedro Abáigar Luquín Servicio de Nefrología, Hospital Universitario de Burgos, Burgos
Keywords: Kaposi's sarcoma, kidney transplant, injuries, inhibitors of calcineurin, i-mTOR

Abstract

Kaposi's sarcoma (KS) is a vascular neoplasm, in which we can distinguish four clinical forms: the classic or Mediterranean, endemic or African, associated with HIV and iatrogenic. Its most frequent clinical manifestations are mucocutaneous lesions and lymph node involvement, although it may manifest with involvement at the visceral level. We present the case of a renal transplant patient who was diagnosed with an intestinal Kaposi's sarcoma, with no associated cutaneous lesions.

References

Gao SJ, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, ET AL. Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med. 1996;335(4):233-41.

Regamey N, Tamm M, Wernli M, Witschi A, Thiel G, Cathomas G, et al. Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. N Engl J Med. 1998;339(19):1358-63.

Hosseini-Moghaddam SM, Soleimanirahbar A, Mazzulli T, Rotstein C, Husain S. Post renal transplantation Kaposi's sarcoma: a review of its epidemiology, pathogenesis, diagnosis, clinical aspects, and therapy. Transpl Infect Dis. 2012;14(4):338-45.

Maluccio M, Sharma V, Lagman M, Vyas S, Yang H, Li B, et al. Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression. Transplantation. 2003;76(3):597-602.

Huber S, Bruns CJ, Schmid G, Hermann PC, Conrad C, Niess H, et al. Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis. Kidney Int. 2007;71(8):771-7.

Mocroft A, Kirk O, Clumeck N, Gargalianos-Kakolyris P, Trocha H, Chentsova N, et al. The changing pattern of Kaposi sarcoma in patients with HIV, 1994-2003: the EuroSIDA Study. Cancer. 2004;100(12):2644-54.

Schwartz RA. Kaposi's sarcoma: an update. J Surg Oncol. 2004;87(3):146-51.

Rivero Fernández M, García Martos M, Sanz Moya P, Vázquez Romero M, Fernández Amago MT, García Benayas MT, et al. Sarcoma de Kaposi con afectación colorrectal y del canal anal. Gastroenterol Hepatol. 2010;33(7):508-11.

Neff R, Kremer S, Voutsinas L, Waxman M, Mitty W Jr. Primary Kaposi's sarcoma of the ileum presenting as massive rectal bleeding. Am J Gastroenterol. 1987;82(3):276-7.

Campistol JM, Gutierrez-Dalmau A, Torregrosa JV. Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcoma. Transplantation. 2004;77(5):760-2.

Published
2018-12-14
How to Cite
1.
Sáez Calero MI, Marín Franco AJ, Santos Barajas JJ, Yépez León G, Tabernero Fernández G, Palacios Ball JB, Abáigar Luquín P. Intestinal Kaposi’s Sarcoma in renal transplant patient. Rev Nefrol Dial Traspl. [Internet]. 2018Dec.14 [cited 2024Dec.28];38(4):268-72. Available from: http://vps-1689312-x.dattaweb.com/index.php/rndt/article/view/373
Section
Case Report